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New Research on Treating Depression


Jan. 30, 2017 The Wall Street Journal

New research on treatments for depression presents an intriguing finding: a healthy diet may help depressed patients.

It is part of the nascent field of nutritional psychiatry which uses changes in diet to help treat mood disorders. Researchers are always looking for new treatments for depression and other mental-health disorders because many people don’t respond to antidepressant medications and psychological therapies.

The study, published Monday in the journal BMC Medicine, found that a third of patients assigned to a group that followed a modified Mediterranean diet met the criteria for remission in 12 weeks, compared with just 8% in a control group. Remission as assessed by a patient’s score on a diagnostic questionnaire used by psychiatrists to determine the severity of depression.

There is a large body of evidence, both observational studies and animal studies, that links diet to the risk of developing depression and the prevalence of depression, said Felice Jacka, a professor of psychiatric epidemiology and nutritional psychiatry at Deakin University in Australia and senior researcher on the study. Dr. Jacka is also president of the International Society for Nutritional Psychiatry Research.

Psychiatrists cautioned that the study provides no evidence that diet changes could replace traditional treatments for depression; but it could be beneficial as an add-on treatment.

It may also be an impractical prescription: cooking healthy meals requires motivation and planning, a big demand for depressed patients. Depressed patients have difficulty putting plans into action so would likely require assistance, experts said.

“They have this sense of fatigue and inability to get up and go, and any mental effort they feel is overwhelming and exhaustive,” said Robert Shulman, associate chairman of psychiatry at Rush University Medical Center in Chicago.

The study, the first randomized controlled one, consisted of 67 people diagnosed and already being treated for a major depressive disorder. The mean age was 40 and most were overweight.

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