Article Bookmarked
Bookmark Removed

Brain’s inability to repair DNA may explain dementia, memory loss


Feb. 10, 2015 Medical News Today

Previously, it was thought ability to repair DNA was the same throughout the body, but new research overturns this idea and shows organs vary in the extent to which they carry out a type of DNA repair called nucleotide excision repair.

This was the finding of a new study led by Nova Southeastern University (NSU) in Fort Lauderdale, FL, that is published in the journal Photochemistry and Photobiology.

For the study, the team investigated a type of DNA repair called nucleotide excision repair (NER). It is one of five types of DNA repair used by mammalian cells, primarily to repair damage caused by a range of cancer-causing agents, including ultraviolet (UV), products of organic combustion, metals and oxidative stress.

NER is a complicated process that requires a high level of metabolic investment by the cell. It mends DNA regions that contain unwanted added molecules that distort the DNA helix and interfere with DNA copying during cell division.

Lead investigator Jean Latimer, associate professor of pharmaceutical sciences at the College of Pharmacy at NSU, and colleagues found that the heart has the greatest ability to repair DNA using NER, followed by the gut, the kidneys, the spleen, the testes and the lungs.

However, the researchers found the brain appears to have no ability to carry out this vital type of DNA repair.

Read More on Medical News Today

Gene Upshaw Player Assistance Trust Fund

Apply Today

All Resources

Tell Me More

How to Be Happy

Public policies based on culture are making people happy.

Read More

6 Strategies for Managing Disappointments

How to navigate the aftereffects of rejection.

Read More

5 Good Ways to Construct Habits

Habit formation doesn't need to feel boring or punishing.

Read More

Are We What We Eat? Nutritional Psychiatry and Brain Health

Our brains are hungry. Here's what to eat.

Read More

Why Microsoft Measures Employee Thriving, Not Engagement

A new way to support and empower your teams.

Read More

The Truth About Fasting and Type 2 Diabetes

Fasting: fad or century old-tradition?

Read More

Homeownership: Understanding Hidden Costs

Learn more about down payments, closing costs and taxes.

Read More

How to Craft a Fulfilling Career

Practical tips for aligning your values with your work.

Read More